This book provides a current understanding of Continuous Renal Replacement Therapies (CRRT) techniques with a focus on drug dosing in critically ill children receiving CRRT. Strategies include the role of therapeutic drug monitoring, effect of CRRT on drug pharmacokinetics, variations in the drugs properties, newer kidney injury biomarkers and simple and easy methods for estimating drug clearance. The conclusion of this book features case reports focused on the patients symptoms and laboratory data as they present in clinical practice and the type of CRRT modality needed to provide quality, safety, and cost-effectiveness of patient care. Pediatric Continuous Renal Replacement Therapy will expand the clinical knowledge and experience of practicing nephrologists and other professionals involved in the care of children suffering from Acute Kidney Injury (AKI) to improve and sustain their quality of life. 

Farahnak Assadi, M.D.

Distinguished Professor, Emeritus 

Department of Pediatrics

Rush University Medical College

Division of Nephrology

Rush Children's Hospital

Chicago, Illinois

USA

Fatemeh Ghane Sharbaf, M.D. 

Associate Professor

Department of Pediatrics 

Section of Nephrology 

Mashhad University of Medical Sciences

Mashhad, Iran

Acute kidney injury.- CRRT as treatment.-  Water and solute movements: basic physiology.- CRRT modalities.- Hemodialysis (diffusive) versus hemofiltraion (Convective) CVVH.- CRRT Principles.- General consideration for CRRT.- Specific consideration for pediatric CRRT.- Vascular access and catheter size.- Blood flow rate (BFR) .- Ultrafiltation rates.- Calculating the desired fluid removal rate.- Replacement/dialysate solutions.- Drug dosing in CRRT.- Blood priming.- Nutrition in CRRT.- Monitoring during CRRT.- Compliance of CRRT.- Replacement/dialysate solution composition.- Factors influencing the clearance of drug during CRRT.- CRRT impact on pharmacokinetic parameters.- Case Studies.-