Alzheimers disease (AD) is the most common cause of dementia in the elderly and is characterized by a progressive memory decline, impairments in language and visual spatial skills, impairments in behavior, resulting in a loss of independence, reduction of quality of life, and ultimately death. In the present study, we have described a facile synthesis of novel promising anti-Alzheimers disease steroidal curcumin derivatives and investigated the importance of incorporating heterocylic moiety to the curcumin nucleus to form new effective hybrid molecules All the tested compounds have been shown to possess anti-Alzheimers disease properties in AD model by enhancing Ach synthesis, GSH, paraoxenase and BCL2 levels while decreasing brain AchE activity, 8-OHG, Caspase-3 and P 53 levels. Finally, the anti-Alzheimers activity displayed by these compounds may be of interest for further derivatization, further studies in the hope of finding more active and selective anti-Alzheimers agents.

Gamal A. Elmegeed: Professor of Hormones and Medicinal Chemistry; Supervisor for many M.Sc. and Ph.D. Theses; Head Researcher, Vice Researcher and/or member for many research projects. Head of medicinal chemistry group at Hormones Dept., Vice president of Hormones Department (2013-2016), Medical Research Division, National Research Centre